Benign Lymphoid aggregates in the bone marrow
The presence of small, benign/reactive lymphoid aggregates in the marrow of HIV-infected individuals has been studied, and most of these aggregates are chiefly composed of T cells or show a mixed ...
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Molecular and Cellular Requirements for the …
Abstract. At sites of chronic inflammation, recruited immune cells form structures that resemble secondary lymphoid organs (SLOs). Those are characterized …
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Tertiary lymphoid structures critical for prognosis in …
B-cells play a key role in cancer suppression, particularly when aggregated in tertiary lymphoid structures (TLS). Here, we investigate the role of B-cells and TLS in endometrial cancer (EC).
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Multiple sclerosis: role of meningeal lymphoid aggregates …
Onset typically occurs during the 20s or early 30s of human adults, with women affected at a 2:1 ratio ... have largely been ineffective for understanding the CNS-compartmentalized pathological process by which meningeal lymphoid aggregates ... we posit that P-MS would be delayed or even prevented. We suggest that meningeal lymphoid aggregates ...
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Tumor-Associated Tertiary Lymphoid Structures: From Basic …
Introduction. The study of tertiary lymphoid structure (TLS) formation, cellular content and function in tumors has progressed tremendously since the initial discovery of their presence in non-small cell lung carcinoma (NSCLC) and their association with more favorable clinical patient outcome ().Numerous investigations on TLS have …
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Tertiary lymphoid structures are critical for cancer …
Tertiary lymphoid structures (TLSs) are ectopic lymphocyte aggregates that form at sites of chronic inflammation, including cancers, in non-lymphoid tissues. …
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Unique CD8 + T cell‐rich lymphoid aggregates in …
aggregates described by a number of authors [reviewed in ref. 7J. To date, most immunophenotypic studies of human uterine tissue have used single-color immunohistochemi-cal staining of sequential frozen sections and have resulted in little information about the extent of T cell aggregates or the spatial relationships of the …
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Tertiary Intratumor Lymphoid Tissue in Colo-Rectal Cancer
Ectopic (or tertiary) lymphoid tissue develops at sites of inflammation or infection in non lymphoid organs and is associated with chronic inflammation. In colon mucosa, small lymphoid aggregates are already present in homeostatic conditions, as part of the gut-associated lymphoid tissue and play an essential role in the immune …
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Group 3 innate lymphoid cells in intestinal health and disease
Shikhagaie, M. M. et al. Neuropilin-1 is expressed on lymphoid tissue residing LTi-like group 3 innate lymphoid cells and associated with ectopic lymphoid aggregates. Cell Rep. 18, 1761–1773 (2017).
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Lymphoid Aggregates in Bone Marrow | Basicmedical Key
Typical neoplastic cells in classical Hodgkin lymphoma. This is the typical appearance of a benign lymphoid aggregate in bone marrow; it is nodular, nonparatrabecular, well circumscribed, and composed of predominantly small mature lymphocytes. Typical immunohistochemical findings in a benign lymphoid aggregate …
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IL-18 associated with lung lymphoid aggregates drives IFNγ …
In agreement with recent observations in the human gastro-intestinal tract we further revealed that IL-18 + macrophages and dendritic cells are in COPD foremost localized to lung lymphoid aggregates. Increased lymphoid aggregates in the lung are a histological hallmark of severe COPD status and this study is the first to highlight that IL …
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The lymphoid system: a review of species differences
The human thymus begins the process of involution in the first 10 years of life and largely consists of fat and connective tissue by the time a human reaches the age of 30. ... Histologic changes in rectal lymphoid aggregates of dogs must be interpreted with caution as self–induced trauma and/or pathology of the adjacent anal glands can ...
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Issues for patchy tissues: defining roles for gut-associated lymphoid …
In mice, the caecum is the equivalent of the human appendix and typically contains a single large aggregate of lymphoid follicles near the tip of the caecum referred to as the 'caecal patch'. Lymphoid tissue in the small intestine and appendix/caecum of both humans and mice are similar in microscopic structure.
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Pancreatic Cancer Chemotherapy Is Potentiated by
We could not detect any difference in the immune infiltrate based on the presence or absence of lymphoid aggregates, in PBS-treated mice (Figure 6 B–G), suggesting that this spatial aggregation of the lymphoid cells (lymphoid aggregate) in the control group was a focal reaction to injection-induced trauma, which was also observed …
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Of mice and lymphoid aggregates: modeling tertiary …
Tertiary lymphoid structures (TLS) are ectopic immune aggregates that form at sites of chronic inflammation such as cancer ( 1 ). By definition, TLS are tight …
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The roles of tertiary lymphoid structures in chronic …
Here, the authors discuss tertiary lymphoid structure (TLS) development, maintenance and function, with a focus on the roles of TLSs in autoimmune disease, …
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The role of lymphatics in intestinal inflammation
Lymphoid aggregates, inflammatory granulomas, and "fat wrapping" (fat creeping) suggest a general failure of lymphatic transport of lipids and inflammatory cells . It was recently proposed that fatty acids released from adipocytes within creeping fat shift the metabolic state of muscle cells directly in the intestinal muscularis externa to ...
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Lymphatic system: Definition, anatomy, functions | Kenhub
The lymphatic system is a network of vessels and organs that regulates the amount of fluid in the human body and defends it against infections. Structure: Lymphatic capillaries; lymphatic vessels, ducts and tracts; primary and secondary lymphoid organs, Function: Fluid regulation; immune surveillance; transport of large molecules Clinical …
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GI biopsies with lymphoid aggregates: What does …
Lymphoid follicle with germinal center (i.e., secondary follicle). Terms frequently used in GI pathology reports. Reactive lymphoid aggregate: A lymphoid …
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Frontiers | Lymphoid Aggregates in the CNS of Progressive …
Figure 1.Ectopic lymphoid structures in progressive MS are characterized by infiltration of lymphocytes, FDCs and plasma cells. (A) Parenchyma of FFPE sections of brain and spinal cord of progressive MS patients were screened for infiltrated regions by H&E staining.(B) IF staining for CD3 + T cells and CD20 + B cells on serial sections were …
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Frontiers | Tertiary lymphoid structures are critical for cancer
Tertiary lymphoid structures (TLSs) are ectopic lymphocyte aggregates that form at sites of chronic inflammation, including cancers, in non-lymphoid tissues. Although the formation of TLSs is similar to that of secondary lymphoid organs, the pathogenic factors leading to TLS formation in cancerous tissues and the mechanisms underlying …
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Organogenesis of lymphoid tissues | Nature Reviews …
The development of lymphoid organs depends on the correct expression of several molecules within a defined timeframe during ontogeny. Although this is an extremely complex process, with each ...
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Tertiary Lymphoid Structures: Diversity in Their Development
In several inflamed tissues, resident fibroblasts can acquire lymphoid-stroma properties and drive the formation of ectopic aggregates of immune cells, named tertiary …
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Development and physiological functions of the …
Primary lymphoid organs, bone marrow and thymus, are the sites for immune cell production, whereas secondary lymphoid organs are sites where …
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Multiple sclerosis: role of meningeal lymphoid aggregates …
Evolution of human gadolinium-enhanced lesions of MS via MRI. ... (at left) and relapsing (right) MS pathology. Meningeal lymphoid aggregates, composed of T and B cells, and follicular ... have largely been ineffective for understanding the CNS-compartmentalized pathological process by which meningeal lymphoid aggregates …
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Tertiary lymphoid structures (TLS) identification and density …
Tertiary lymphoid structures (TLS) are ectopic aggregates of lymphoid cells in inflamed, infected, or tumoral tissues that are easily recognized on an H&E histology slide as discrete entities, distinct from lymphocytes. TLS are associated with improved cancer prognosis but there is no standardised method available to quantify their …
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processing of human lymphoid aggregates
This process resulted in the ... Human lymphoid and myeloid cell development in NOD/LtSz-scid ... Go to Product Center. CD8+ T cells in human uterine endometrial lymphoid aggregates ..., CD8 + T cells in human uterine endometrial lymphoid aggregates: evidence for accumulation of cells by trafficking. ... (The Image Processing …
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Lymphocytosis, lymphadenopathy: benign or malignant?
More than one-half had no evidence of lymphoid aggregates, despite immunohistochemical staining. This is in contrast to MBL, in which the majority have lymphoid infiltrates on bone marrow biopsy. 13 Whether small non-CLL monoclonal clones detected in bone marrow will progress to clinically significant lymphoproliferative …
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21.1 Anatomy of the Lymphatic and Immune Systems
The human body contains approximately 10 12 lymphocytes. B Cells. B cells are immune cells that function primarily by ... It is through this process that the body (ideally) learns to destroy only pathogens and leaves the body's own cells relatively intact. ... consists of an aggregate of lymphoid follicles directly associated with the mucous ...
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The roles of tertiary lymphoid structures in chronic diseases
Maturation of tertiary lymphoid structures. a, In the kidney and most other organs, arteries, veins and lymphatic vessels run together. Tertiary lymphoid structures (TLSs) first appear as small aggregates containing mainly T cells and B cells at perivascular sites, and then expand and mature into clusters with distinct B cell and T cell areas.
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